mcq on pharmacology 1. The metabolites of hard drugs are frequently toxic oxidation products. Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p148-151. c) Drug C has the most appropriate pharmacodynamic properties of the three drugs shown as non-toxic effects are achieved within the therapeutic window. less than normal therapeutic response to drug therapy ? Question # 17 (Multiple Choice) Mixed function oxidases system is referred to as mediating: Question # 18 (Multiple Answer) Characteristics of drug-protein binding, (A) generally theextent of drug-protein binding parallels drug lipids liability, (D) sulfonamides may displace unconjugated bilirubin from albumin-binding sites (because neonatal bilirubin encephalopathy). , 21. Question # 11 (Multiple Choice) Termination of pharmacological action of thiopental occurs mainly by: Question # 12 (Multiple Answer) Concerning influence of age on drug responses:variation in response usually due to: Question # 13 (Multiple Choice) Reaction type associated with inactivation of succinylcholine, atracurium, and mivacurium. , 20 d) All three drugs have appropriate pharmacodynamic properties as they all achieve maximal physiological effects and have concentrations within the therapeutic window. The pulmonary epithelium as the primary site for metabolism. All other drugs mentioned have significant first pass metabolism. The examination is scored by clicking 'Grade Test' at the bottom of the form. , 14 a) Bile acid synthesis. Please use the Scantron Sheet provided. DRUGS OF ABUSE. Protein binding of a drug helps in. b) Prolonging half life. Distribution of drugs to specific tissues STUDY. Question # 11 (Multiple Choice) Termination of pharmacological action of thiopental occurs mainly by: Question # 12 (Multiple Answer) Concerning influence of age on drug responses:variation in response usually due to: Question # 13 (Multiple Choice) Reaction type associated with inactivation of succinylcholine, atracurium, and mivacurium. Parenteral administration: a) Cannot be used with unconsciousness patients Used for the study of drug absorption & metabolism in human. If hepatic blood flow is 1500 mls/min, the hepatic clearance is: A. , 19 How the body moves and affects a drug. It is detoxified to form p-Acetyl amino phenol. , 7 PLAY. a) Distribution. Question # 19 (Multiple Answer) Factors affecting hepatic drug clearance: (A) drug delivery to liver elimination sites. c. Chlordiazepoxide. In this case, if 500 mg is present in the body at time zero, after metabolism, 450 mg may be present at 1 hour and 400 mg at 2 hours (illustrating a maximal clearance of 50 mg/h and no specific half-life). e. Zolpidum. b. Meprobamate. Try this amazing Pharmacology Drug Metabolism quiz which has been attempted 2663 times by avid quiz takers. Flashcards. , 3 tianaky. large intestine (pH=8) ? THC is a. Delta-9-tetrahydrocannabinol b. Tri-hydro-cannabinol c. Tri-hexa-cannabinate d. Cis-5-tetrahydrocannabinate e. Obtained from poppy leaves Learn quiz drug metabolism medicinal chemistry with free interactive flashcards. There are 50 multiple choice questions worth 1. We no longer publish the answers to the MCQs in the journal. glucose in liver. It has an octanol coefficient of 10 B. Lipid Metabolism: MCQs (Cholesterol, Triglycerides, and Other Lipids) 1) The cholesterol serves as the precursor for the following biosynthetic pathways EXCEPT. Purine and Pyrimidine Metabolism: MCQ. d) … This is a self-grading exam. , 11 pdf), Text File (. Learn. Question # 14 (Multiple Answer) Phase II and reactions: Question # 15 (Multiple Choice) Factors affecting renal clearance of drugs: Question # 16 (Multiple Choice) Concerning drug-plasma protein binding: Question # 17 (Multiple Choice) Mixed function oxidases system is referred to as mediating: Question # 18 (Multiple Answer) Characteristics of drug-protein binding. The functioning of the liver plays a significant role in the metabolism of drugs. a lower oral dosage should be used A drug that is a weak organic acid (pK=3) would be least ionized in the: ? Question # 1 (Multiple Answer) Factors that could change intrinsic hepatic clearance include: Question # 2 (True/False) In rheumatoid arthritis patients, increased alpha1-acidic glycoprotein may be associated with increased lidocaine protein binding. , 5 A) drug metabolism by gastrointestinal flora B) drug hydrophilicity (opposite of lipophilicity) C) drug instability in gastric acid D) presence of food in the GI tract E) drug-drug interactions Question # 9 (Multiple Answer) Drug characteristics contributing to reliable transdermal drug absorption: A) molecular weight less than 1000 Almost complete metabolism of morphine. , 18 Pharm9: Drug Metabolism 10 Questions | By Stephengibbs | Last updated: Jul 30, 2011 | Total Attempts: 1438 Questions All questions 5 questions 6 questions 7 questions 8 questions 9 questions 10 questions C) , 9 15. metabolism (drug biotransformation), to illustrate the wide-ranging medical implications of such biological processes and to provide the reader with a perspective on current research in this area. to increased metabolism of warfarin like drugs? Pick out the parenteral route of medicinal agent administration: a) Rectal b) Oral c) Sublingual d) Inhalation 015. Answers are entered by clicking the button corresponding to your selection. Used for the study of drug effectiveness in treating the disease & short term side effects in . MCQ Kinetics, Dynamics. , 17 2. Match. a) LD 50. b) LD 1. c) ED 50. d) ED 99. The enzyme system responsible for the metabolism of most drugs is: A) P-glycoprotein. Medicinal chemistry exam 1 - Free download as PDF File ( Medicinal chemistry 1 exam questions. All of the following are recognized adverse effects of isoniazid EXCEPT a. Also explore over 9 similar quizzes in this category. , 10 Home MCQ MCQ TEST (1) PHARMACOLOGY-IV (Clinical Pharmacy and drug interaction) T 4.8.5 MCQ TEST (1) PHARMACOLOGY-IV (Clinical Pharmacy and drug interaction) T 4.8.5 ... A. d. Triazolam. The plasma concentration after giving it is ... hepatic first pass metabolism. Hard drugs are "non-metabolizable drugs" or drugs which are metabolized to biologically active metabolites. As drug concentration increases, metabolism shifts from first-order to zero-order kinetics. E) HMG-CoA. In mammals, carbohydrates are stored in the form of. Which … D) cytochrome P-450. Question # 4 (Multiple Answer) Characteristic(s) of a drug whose action is terminate by redistribution include: (C) eventually concentrates usually in adipose (fat) tissue. Question # 9 (Multiple Answer) Drug characteristics contributing to reliable transdermal drug absorption: A) molecular weight less than 1000 txt) or read online for free. 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